Isotretinoin and Inflammatory Bowel Disease

included gastric antral vascular ectasia (GAVE) (6), GAVE and AD (6), tumor (9), polyps (2), Crohn’s disease (3), NSAID ulceration (3), peptic ulcer disease (3), varices (2), small bowel ulcers (4), Dieulafoy (1), and miscellaneous (11). Carey described advanced age as the only predictive factor in overt OGB. However, in our data set (using multivariate analysis), both transfusion dependence (P = 0.005) and co-morbidity (P < 0.0001) were significant predictive factors. The management was altered in 42% and 23% in the overt bleeders and occult bleeders, respectively (P < 0.025). This was in the form of endoscopic treatment of angioectasia: heater probe (16), variceal glueing (1), polypectomy (1), surgery (12), drug therapy (11: Helicobacter eradication/proton pump inhibitors [2], thalidomide [3], beta blockers [1], azathioprine [1]/withdrawal of nonsteroidal antiinflammatory drugs [4]), and initiation of a gluten-free diet (1). In conclusion, transfusion dependence and comorbidity may also be significant predictors of a positive diagnostic yield. Further CE studies are required to validate these criteria, ensuring efficient use of the CE service.